The clinical case of a combined new coronavirus infection and whooping cough in an unvaccinated child.

Whooping cough remains a life-threatening infection, especially for unvaccinated young children. The article describes a case of severe and non-smooth course of whooping cough in an unvaccinated, girl of 4 months of life from the family hearth of whooping cough and. COVID-19. There were cases of COVID-19 and. whooping cough, in adults in the family, occurring under the mask of a mild respiratory infection, not verified before they were detected, in a child, and. did. not require hospitalization. The combined, course of two infectious diseases COVID-19 and. whooping cough, in a 4-month-old. unvaccinated, girl contributed, to the prolongation of the duration o f whooping cough, prolonged release o f SARS-COV-2 RNA, the late appearance of hematological changes typical o f whooping cough, the development o f respiratory delays and re-hospitalization o f a patient with prolonged respiratory support. In the context of the COVID-19 pandemic, the coverage of routine vaccination, has significantly decreased, as a result of which, children of the first years of life have become more vulnerable to vaccine-controlled, infections, which, causes the risk of combined, infections.Copyright © 2022 Authors. All rights reserved.

The clinical case of a combined new coronavirus infection and whooping cough in an unvaccinated child.

Whooping cough remains a life-threatening infection, especially for unvaccinated young children. The article describes a case of severe and non-smooth course of whooping cough in an unvaccinated, girl of 4 months of life from the family hearth of whooping cough and. COVID-19. There were cases of COVID-19 and. whooping cough, in adults in the family, occurring under the mask of a mild respiratory infection, not verified before they were detected, in a child, and. did. not require hospitalization. The combined, course of two infectious diseases COVID-19 and. whooping cough, in a 4-month-old. unvaccinated, girl contributed, to the prolongation of the duration o f whooping cough, prolonged release o f SARS-COV-2 RNA, the late appearance of hematological changes typical o f whooping cough, the development o f respiratory delays and re-hospitalization o f a patient with prolonged respiratory support. In the context of the COVID-19 pandemic, the coverage of routine vaccination, has significantly decreased, as a result of which, children of the first years of life have become more vulnerable to vaccine-controlled, infections, which, causes the risk of combined, infections.Copyright © 2022 Authors. All rights reserved.

The clinical case of a combined new coronavirus infection and whooping cough in an unvaccinated child.

Whooping cough remains a life-threatening infection, especially for unvaccinated young children. The article describes a case of severe and non-smooth course of whooping cough in an unvaccinated, girl of 4 months of life from the family hearth of whooping cough and. COVID-19. There were cases of COVID-19 and. whooping cough, in adults in the family, occurring under the mask of a mild respiratory infection, not verified before they were detected, in a child, and. did. not require hospitalization. The combined, course of two infectious diseases COVID-19 and. whooping cough, in a 4-month-old. unvaccinated, girl contributed, to the prolongation of the duration o f whooping cough, prolonged release o f SARS-COV-2 RNA, the late appearance of hematological changes typical o f whooping cough, the development o f respiratory delays and re-hospitalization o f a patient with prolonged respiratory support. In the context of the COVID-19 pandemic, the coverage of routine vaccination, has significantly decreased, as a result of which, children of the first years of life have become more vulnerable to vaccine-controlled, infections, which, causes the risk of combined, infections.Copyright © 2022 Authors. All rights reserved.

safety of antibodies to measles, mumps, rubella and diphtheria in patients with juvenile idiopathic arthritis

Introduction. The issue of protection against vaccine-preventable diseases has acquired new urgency in connection with the decrease in the vaccination rate established by WHO against the background of the COVID-19 pandemic. This creates the conditions for outbreaks and puts patients with immunopathological diseases at particular risk, who are most often not vaccinated from the moment of diagnosis Purpose of the study – to assess the safety of specific antibodies to measles, mumps, rubella and diphtheria in children with JIA, depending on the duration of vaccination, the duration of the disease and the therapy received. Materials and methods. The vaccination rate of 171 children with juvenile idiopathic arthritis (JIA) aged (11,31±0,31 years) with the duration of the disease at the time of examination was 4,69±0,29 years, who had previously received 1-2 vaccinations against measles, mumps, rubella and 3-6 vaccinations against diphtheria. Antibodies to these infections were determined by ELISA. Results. 42.1% of children had no protective titers of antibodies to measles, 19,9% – to mumps, 9,4% – to rubella and 16,4% – to diphtheria. Among 93 vaccinated and revaccinated patients, there were no protective titers of antibodies to measles – 40,9% (38 children), mumps – 13,9% (13 people), rubella – 5,4% (5 children), and among 78 vaccinated once, respectively: measles – 43.6% (34 children), mumps – 25.6% (20 children), rubella – 14,1% (11). The level of protection against diphtheria was comparable for those who received 3-5 vaccinations. Depending on the therapy, 3 groups were identified: group 1-71 children received metatrexate and glucocorticosteroids, 2-82 children received modifying anti-rheumatic drugs (DMARD) and 18 children without this therapy (Group 3). Children of the 2nd group were on average older (12,48±0,42 years) than in the 1st and 3rd groups (10,04±0,48 and 10,96±0,96 years, respectively), they had significantly more frequent systemic variant and polyarthritis (64,6% compared to 36,6% and 16,7%, px2<0,001). The number of vaccine doses received by children in all groups before the onset of the disease did not significantly differ. The average level of antibodies to measles in children of group 2 (0,32±0,07 IU/ml) was 2,8 times less than in group 3 and significantly less than in group 1 (0,78±0,16, Pt=0.009), the average value of antibodies to rubella was also significantly less in group 2 (84,48±7,34 IU/ml) than in group 1 (109,73±8,09, Pt=0,022) and in group 3 (120,01±15,42, Pt=0,042). The analysis showed that the safety of antibodies to antigens of live vaccines, especially against measles, is negatively affected by the duration of the disease and the nature of therapy. Children who received combined therapy with anti-TNF, anti-IL-6 and anti-CD-80 drugs had a longer duration of the disease (7,5±0,97 years)=0,00082 compared to those who received only anti-IL-6 (2,9±0,7 years) and anti-TNF therapy (6,1±0,5 years) and with a comparable number of vaccine doses received, significantly lower average values of antibodies and a larger number of unprotected ones. Conclusions. The duration of the disease, the lack of timely age-related revaccinations, as well as the presence of combination therapy aimed at suppressing various mechanisms of the immune response in children with JIA are factors that lead to an increase in the number of unprotected from controlled infections. Immunity to measles suffers the most – 40.9% of revaccinated people are unprotected.

Pediatric multisystem inflammatory syndrome associated with a new coronavirus infection: unresolved issues

Since March 2020, the first reports have appeared about the increasing, almost everywhere, number of children who have undergone a new coronovirus infection caused by SARS-Cov-2 with a symptom complex resembling the manifestations of Kawasaki disease. A special feature of the clinical manifestations of this syndrome, which is called “Pediatric multisystem inflammatory syndrome associated with COVID-19”, is the high incidence of life-threatening conditions caused by the sharp development of arterial hypotension against the background of cardiogenic or vasogenic shock. In St. Petersburg, since the end of November 2020, there has been a sharp surge in admissions of children to the ICU of various hospitals with the clinic of Pediatric multisystem inflammatory syndrome, who have laboratory confirmation of the transferred COVID-19. The purpose of this article is to attract the attention of doctors of various profiles, to combine efforts to study this pathology, to determine the criteria for verifying the diagnosis, optimal treatment regimens and dispensary monitoring of patients who have been ill. © 2021 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.